Cockroach Periplaneta americana Extract as Systemic Anti-inflammatory in Rat of SIRS Model

Abstract

Systemic inflammatory response syndrome (SIRS) is a phenomenon of systemic hyperinflammation mediated by innate immune response due to exposure to infection or non-infection. This study aims to analyze the effectiveness of anti-inflammatory cockroach P. americana extract through clinical animal models. Induction of SIRS through cecal ligation and puncture (CLP). The animal model was used 20 10-week-old male Sprague Dawley rats that received CLP and were treated with NaCl 0.9% 0.2 ml/day, dexamethasone 0.75 mg/kg BW, cockroach P. americana extract (EKP) 50 mg/kg BW, and 100 mg/kg BW. Therapy was administered orally at 24 and 48 hours after CLP. Body temperature variables showed no significant difference between groups given NaCl 0.9%, dexamethasone, and EKP 50 mg/kg BW (P > 0.05), but significantly different (lower temperature below normal) with the EKP 100 mg/kg BW (P < 0.05). The variables of breaths, heart rate, and total leukocytes did not show significant differences between each group (P > 0.05). The survival percentage until the end of the study in the NaCl 0,9%, dexamethasone, EKP 50 mg, and EKP 100 mg groups was respectively 60%, 80%, 100%, and 60%. EKP 50 mg/Kg BW has the potential as a systemic anti-inflammatory in rats of SIRS model.